Dry Column Vacu m Chromatography Sejer Pedersen,* Christoph Rosenbohm Daniel

Abstract

Chromatographic purification is an integrated part of or- ganic synthesis. The Dry Column Vacuum Chromatography pre- sented here, has excellent resolving power, is easily applied to large scale chromatography (up to 100 g) and is fast. Furthermore, the technique is economical and environmentally friendly due to signif- icant reductions in solvent and the amount of silica used. Therefore, it is an excellent alternative to the commonly used Flash Column Chromatography for purification in organic synthesis.