Objectives: We investigated the effects of short-term use of atorvastatin on CD34+/VEGF-R2+/CD133+/CD45- endothelial progenitor cell (EPC) count after on-pump coronary artery bypass surgery (CABG). Methods: Between Feb-2010 and May-2010, we randomly assigned, in a placebo-controlled, double-blind study, 60 consecutive patients who underwent isolated, first-time CABG to receive either 14-day atorvastatin (40 mg/day) or placebo preoperatively. Urgent CABG and recent myocardial infarction were excluded. EPCs were quantified (cells/μl) by flow cytometric phenotyping obtained from venous blood samples collected preoperatively (T1), 6-hours (T2), and on the 5th day postoperatively (T3). Levels of markers of inflammation and serum cardiac troponin I were also measured preoperatively and daily until day-5 after surgery. Results: There were no differences in baseline risk factors including cholesterol profiles, and EuroSCORES between the groups. The composite primary end-point, favored statin group with higher amount of circulating, early EPC count (cells/μl) at all time points compared with placebo (T1, 2. 30 ± 0.02 versus 1. 58 ± 0. 03, p<0.001; T2, 5. 00 ± 0. 06 versus 2. 19 ± 0.06, p<0. 001; T3, 3. 03 ± 0. 08 versus 1. 78 ± 0. 02, p<0.001). Postoperative hsCRP rise were inversely correlated with EPC count, and were significantly lower in the statin group (T1, 0. 8 ± 0. 1 versus 2. 2 ± 1. 5, p<0.001; T2, 72. 9 ± 3. 2 versus 96. 0 ± 3. 6, p<0.001; T3, 4. 3 ± 1. 2 versus 11. 4 ± 4. 1, p<0.001). Furthermore, the incidence of postoperative atrial fibrillation was significantly lower in the statin group compared to placebo (3. 3% versus 23%, p = 0. 02). Conclusions: Short-term atorvastatin use increases circulating early EPCs both pre- and post-operatively and is associated with better preservation of sinus rhythm and reduced hsCRP levels. (ClinicalTrials. gov number, NCT01096875) © 2011 Springer Science+Business Media, LLC.
CITATION STYLE
Baran, Ç., Durdu, S., Dalva, K., Zaim, Ç., Dogan, A., Ocakoglu, G., … Akar, A. R. (2012). Effects of Preoperative Short Term Use of Atorvastatin on Endothelial Progenitor Cells after Coronary Surgery: A Randomized, Controlled Trial. Stem Cell Reviews and Reports, 8(3), 963–971. https://doi.org/10.1007/s12015-011-9321-z
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