Detailed in this communication is an efficient synthetic approach towards the guttiferone family of natural products. Oxidatively unraveling a para-quinone monoketal followed by consecutive 5-exo radical cyclizations provides the bicyclic core. An additional strength of this approach is a late stage asymmetric desymmetrization of an advanced symmetric intermediate. © 2010 Royal Society of Chemistry.
CITATION STYLE
McGrath, N. A., Binner, J. R., Markopoulos, G., Brichacek, M., & Njardarson, J. T. (2011). An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products. Chemical Communications, 47(1), 209–211. https://doi.org/10.1039/c0cc01419b
Mendeley helps you to discover research relevant for your work.