Endocrine-Disrupting Chemicals

Abstract

Endocrine-disrupting chemicals (EDC) are implicated in the disruption of the homeostatic milieu of living beings through their adverse effects on hormonal and metabolic processes. Unfortunately, most humans in almost all age-groups are likely to have been exposed to EDC in their lifetimes, and numerous studies provide evidence of detectable levels of these compounds in circulation and in tissues. While multiple endocrine pathways display evidence of disruption, this chapter focuses on the metabolic consequences of these chemicals, particularly on glucose homeostasis, body weight and adiposity, as well as atherosclerosis. Evidence-based recommendations are formulated that can minimize exposure to EDC and promote cardiometabolic health.