Endometrial cancer

Abstract

Endometrial cancer is the second most common gynaecological cancer in England and Wales and appears to be increasing in incidence. There is a general impression that this is a treatable cancer with a good prognosis. However, considering that 75% of women present with disease confined to the uterus, the overall 5 year survival rate of 70% is disappointing. In this article we review the risk factors predisposing to the disease, the presentation, diagnosis and treatment of endometrial cancer. While hysterectomy continues to be the mainstay of treatment, the contribution of lymphadenectomy and adjuvant radiotherapy to improving overall survival is examined. Further research in the form of large-randomised trials is necessary to improve the outcome for women with this disease. © 2004 Elsevier Ltd. All rights reserved.