Background: The onset of schizophrenia is associated with genetic, symptomatic, social and environmental risk factors. The aim of the present study was to determine which environmental factors may contribute to a prediction of a first psychotic episode in subjects at Ultra High Risk (UHR) for developing psychosis. Method: We included 72 UHR subjects and followed them over a period of 36. months, of whom nineteen (26.4%) made a transition to psychosis. We applied survival analyses to determine associations between a transition to psychosis and environmental factors and social adjustment. To determine which items are the best predictors of transition to a first psychotic episode, Cox Regression analyses were applied. Results: Urbanicity, receiving state benefits and poor premorbid adjustment (PMA) significantly influenced the transition to psychosis. Urbanicity (Wald = 10.096, p = 001, HR = 30.97), social-sexual aspects (Wald = 8.795, p = 003, HR = 1.91) and social-personal adjustment (Wald = 10.794, p = 001, HR = 4.26) appeared to be predictors for developing psychosis in our UHR group. Conclusions: Environmental characteristics and social adjustment are predictive of transition to a psychosis in subjects at UHR. These characteristics should be implemented in a model for prediction of psychosis. Such a model would be more specific than current models and may lead to patient-specific preventive interventions. © 2010 Elsevier B.V.
CITATION STYLE
S., D., D.H., N., D., V., H.E., B., R., van de F., L., de H., & D.H., L. (2011). Environmental factors and social adjustment as predictors of a first psychosis in subjects at ultra high risk. Schizophrenia Research, 125(1), 69–76. Retrieved from http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L51091218 http://dx.doi.org/10.1016/j.schres.2010.09.007
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