Eradication

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Abstract

If Helicobacter pylori is present, duodenal and gastric ulcers are now accepted as indications for treatment aimed at eradicating the infection. Strong arguments can also be made for treating non-ulcer dyspepsia associated with H. pylori gastritis. A simple inexpensive treatment is not yet available, however. Triple treatment with bismuth and two antibiotics is effective but patient compliance may be low because of side effects and the number of tablets to be taken. Triple treatment with H2 receptor antagonists and two antibiotics is also effective. Dual therapy with omeprazole and an antibiotic gives varying results: timing, dose, and formulation are critical to achieve success with this treatment but when optimal give good results. Two antibiotics and a proton pump inhibitor are the most effective treatment available. Reinfection rarely occurs after successful eradication.

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O’Morain, C., & Lamouliatte, H. (1994). Eradication. Current Opinion in Gastroenterology. https://doi.org/10.2307/j.ctv29sfz3r.10

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