European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): part II.
European Urology (2008)
- PubMed: 18191015
Available from www.ncbi.nlm.nih.gov
or
Abstract
OBJECTIVES: The first consensus report that had been presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, The Netherlands. METHODS: Medical oncologists, urologic surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference and incorporated the new data into updated and revised guidelines. As for the first meeting the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. RESULTS: The second part of the consensus paper includes the treatment of metastasised disease, residual tumour resection, salvage therapy, follow-up, and late toxicities. CONCLUSIONS: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early-stage as well as of advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged.
Available from www.ncbi.nlm.nih.gov
Page 1
European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): part II.
74 75 76 77
european urology 53 (2008) 497–5135
Department of Urology, Rudolfstiftung, Vienna, Austria
6Niels E. Skakkebaek , Aslam Sohaib , Sergei Tjulandin , Padraig Warde ,
Stefan Weinknecht
78
, Lothar Weissbach
79
, Christian Wittekind
80
, Eva Winter
81
,
Lori Wood
82
, Hans von der Maase
83
1
Department of Urology, Krankenhaus Maria-Hilf, Krefeld, Germany
2
Department of Hemato-Oncology, Vivantes Klinikum Am Urban, Berlin, Germany
3
Department of Radiooncology, Allg. Krankenhaus, Hagen, Germany
4
Department of Urology, Klinikum Kassel, GermanyReview – Testis Cancer
European Consensus Conference on Diagnosis and Treatment
of Germ Cell Cancer: A Report of the Second Meeting of the
European Germ Cell Cancer Consensus Group (EGCCCG): Part II
Susanne Krege
1,
*
,Jo¨rg Beyer
2
, Rainer Souchon
3
, Peter Albers
4
, Walter Albrecht
5
,
Ferran Algaba
6
, Michael Bamberg
7
, Istva´n Bodrogi
8
, Carsten Bokemeyer
9
,
Eva Cavallin-Sta˚hl
10
, Johannes Classen
11
, Christoph Clemm
12
,
Gabriella Cohn-Cedermark
13
, Ste´phane Culine
14
, Gedske Daugaard
15
,
Pieter H.M. De Mulder
16
, Maria De Santis
17
, Maike de Wit
18
, Ronald de Wit
19
,
Hans Gu¨nter Derigs
20
, Klaus-Peter Dieckmann
21
, Annette Dieing
22
, Jean-Pierre Droz
23
,
Martin Fenner
24
, Karim Fizazi
25
, Aude Flechon
26
, Sophie D. Fossa˚
27
,
Xavier Garcia del Muro
28
, Thomas Gauler
29
, Lajos Geczi
30
, Arthur Gerl
31
,
Jose Ramon Germa-Lluch
32
, Silke Gillessen
33
,Jo¨rg T. Hartmann
34
, Michael Hartmann
35
,
Axel Heidenreich
36
, Wolfgang Hoeltl
37
, Alan Horwich
38
, Robert Huddart
39
,
Michael Jewett
40
, Johnathan Joffe
41
, William G. Jones
42
,La´szlo´ Kisbenedek
43
,
Olbjørn Klepp
44
, Sabine Kliesch
45
, Kai Uwe Koehrmann
46
, Christian Kollmannsberger
47
,
Markus Kuczyk
48
, Pilar Laguna
49
, Oscar Leiva Galvis
50
, Volker Loy
51
,
Malcolm D. Mason
52
, Graham M. Mead
53
, Rolf Mueller
54
, Craig Nichols
55
,
Nicola Nicolai
56
, Tim Oliver
57
, Dalibor Ondrus
58
, Gosse O.N. Oosterhof
59
, Luis Paz-Ares
60
,
Giorgio Pizzocaro
61
,Jo¨rg Pont
62
, Tobias Pottek
63
, Tom Powles
64
, Oliver Rick
65
,
Giovanni Rosti
66
, Roberto Salvioni
67
, Jutta Scheiderbauer
68
, Hans-Ulrich Schmelz
69
,
Heinz Schmidberger
70
, Hans-Joachim Schmoll
71
, Mark Schrader
72
, Felix Sedlmayer
73
,
available at www.sciencedirect.com
journal homepage: www.europeanurology.comDepartment of Pathology, Fundacion Puigvert, Barcelona, Spain
7
Department of Radiooncology, Universita¨t Tu¨bingen, Germany
8
National Institute of Oncology, Chemotherapy and Clinical Pharmacology, Budapest, Hungary
9
Department of Hemato-Oncology, Universita¨t Hamburg, Germany
10
Department of Oncology, University Hospital Lund, Sweden
11
Department of Radiooncology, St. Vincentius Kliniken, Karlsruhe, Germany
12
Department of Oncology, Klinikum rechts der Isar, Mu¨nchen, Germany
0302-2838/$ – see back matter# 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved. doi:10.1016/j.eururo.2007.12.025
european urology 53 (2008) 497–5135
Department of Urology, Rudolfstiftung, Vienna, Austria
6Niels E. Skakkebaek , Aslam Sohaib , Sergei Tjulandin , Padraig Warde ,
Stefan Weinknecht
78
, Lothar Weissbach
79
, Christian Wittekind
80
, Eva Winter
81
,
Lori Wood
82
, Hans von der Maase
83
1
Department of Urology, Krankenhaus Maria-Hilf, Krefeld, Germany
2
Department of Hemato-Oncology, Vivantes Klinikum Am Urban, Berlin, Germany
3
Department of Radiooncology, Allg. Krankenhaus, Hagen, Germany
4
Department of Urology, Klinikum Kassel, GermanyReview – Testis Cancer
European Consensus Conference on Diagnosis and Treatment
of Germ Cell Cancer: A Report of the Second Meeting of the
European Germ Cell Cancer Consensus Group (EGCCCG): Part II
Susanne Krege
1,
*
,Jo¨rg Beyer
2
, Rainer Souchon
3
, Peter Albers
4
, Walter Albrecht
5
,
Ferran Algaba
6
, Michael Bamberg
7
, Istva´n Bodrogi
8
, Carsten Bokemeyer
9
,
Eva Cavallin-Sta˚hl
10
, Johannes Classen
11
, Christoph Clemm
12
,
Gabriella Cohn-Cedermark
13
, Ste´phane Culine
14
, Gedske Daugaard
15
,
Pieter H.M. De Mulder
16
, Maria De Santis
17
, Maike de Wit
18
, Ronald de Wit
19
,
Hans Gu¨nter Derigs
20
, Klaus-Peter Dieckmann
21
, Annette Dieing
22
, Jean-Pierre Droz
23
,
Martin Fenner
24
, Karim Fizazi
25
, Aude Flechon
26
, Sophie D. Fossa˚
27
,
Xavier Garcia del Muro
28
, Thomas Gauler
29
, Lajos Geczi
30
, Arthur Gerl
31
,
Jose Ramon Germa-Lluch
32
, Silke Gillessen
33
,Jo¨rg T. Hartmann
34
, Michael Hartmann
35
,
Axel Heidenreich
36
, Wolfgang Hoeltl
37
, Alan Horwich
38
, Robert Huddart
39
,
Michael Jewett
40
, Johnathan Joffe
41
, William G. Jones
42
,La´szlo´ Kisbenedek
43
,
Olbjørn Klepp
44
, Sabine Kliesch
45
, Kai Uwe Koehrmann
46
, Christian Kollmannsberger
47
,
Markus Kuczyk
48
, Pilar Laguna
49
, Oscar Leiva Galvis
50
, Volker Loy
51
,
Malcolm D. Mason
52
, Graham M. Mead
53
, Rolf Mueller
54
, Craig Nichols
55
,
Nicola Nicolai
56
, Tim Oliver
57
, Dalibor Ondrus
58
, Gosse O.N. Oosterhof
59
, Luis Paz-Ares
60
,
Giorgio Pizzocaro
61
,Jo¨rg Pont
62
, Tobias Pottek
63
, Tom Powles
64
, Oliver Rick
65
,
Giovanni Rosti
66
, Roberto Salvioni
67
, Jutta Scheiderbauer
68
, Hans-Ulrich Schmelz
69
,
Heinz Schmidberger
70
, Hans-Joachim Schmoll
71
, Mark Schrader
72
, Felix Sedlmayer
73
,
available at www.sciencedirect.com
journal homepage: www.europeanurology.comDepartment of Pathology, Fundacion Puigvert, Barcelona, Spain
7
Department of Radiooncology, Universita¨t Tu¨bingen, Germany
8
National Institute of Oncology, Chemotherapy and Clinical Pharmacology, Budapest, Hungary
9
Department of Hemato-Oncology, Universita¨t Hamburg, Germany
10
Department of Oncology, University Hospital Lund, Sweden
11
Department of Radiooncology, St. Vincentius Kliniken, Karlsruhe, Germany
12
Department of Oncology, Klinikum rechts der Isar, Mu¨nchen, Germany
0302-2838/$ – see back matter# 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved. doi:10.1016/j.eururo.2007.12.025
Page 2
european urology 53 (2008) 497–51349813
Department of Oncology-Pathology, Radiumhemmet Karolinska Hospital, Stockholm, Sweden
14
Department of Oncology, CRLC Val d’Aurelle, Montpellier, France
15
Department of Oncology, Rigshospitalet, Finsen Center, Kopenhagen, Denmark
16
Department of Internal Medicine, Oncology, University Hospital Nijmegen, The Netherlands
17
Department of Oncology, Kaiser St. Josef Hospitel, Vienna, Austria
18
Department of Hemato-Oncology, Krankenhaus Neuko¨lln, Berlin, Germany
19
Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands
20
Department of Hemato-Oncology, Sta¨dt. Kliniken, Frankfurt, Germany
21
Department of Urology, Albertinen-Hospital, Hamburg, Germany
22
Department of Hemato-Oncology, Universita¨t Charite´ Mitte, Berlin, Germany
23
Department of Oncology, Medical Centre Leon Berard, Lyon, France
24
Department of Hemato-Oncology, Universita¨t Hannover, Germany
25
Department of Hemato-Oncology, Institute Gestave Roussy, Villejuif, France
26
Department of Medical Oncology, Centre Leon Berard, Lyon, France
27
Department of Radiooncology, The Norwegian Radium Hospital, Oslo, Norway
28
Department of Oncologia Medica, Hospital Furan 1 Reynals, Hospitalet de Llobregat, Spain
29
Department of Oncology, Universita¨t Essen, Germany
30
National Institute of Oncology, Budapest, Hungary
31
Oncologist, Mu¨nchen, Germany
32
Department of Medical Oncology, Institut Catala d’Oncologia, Barcelona, Spain
33
Department of Hemato-Oncology, Hospital, St. Gallen, Switzerland
34
Department of Hemato-Oncology, Universita¨t Tu¨bingen, Germany
35
Urologist, Hamburg, Germany
36
Department of Urology, Universita¨t Ko¨ln, Germany
37
Department of Urology, Kaiser-Franz-Josef Hospital, Vienna, Austria
38
Department of Radiotherapy and Oncology, The Royal Marsden Hospital, Sutton, UK
39
Department of Radiotherapy and Oncology, The Royal Marsden Hospital, Sutton, UK
40
Department of Urology, Princess Margaret Hospital, Toronto, Canada
41
Department of Oncology, Macmillan Consultant in Medecal, Leeds, UK
42
Department of Radiotherapy, Cookridge Hospital, Leeds, UK
43
Department of Urology, Ferenc Jahn South-Pest Teaching Hospital. Budapest, Hungary
44
Department of Oncology, Trondheim University Hospital, Norway
45
Department of Urology, Universita¨t Mu¨nster, Germany
46
Department of Urology, Theresienkrankenhaus, Mannheim, Germany
47
Department of Oncology, British Columbia Cancer Agency, Vancouver, Canada
48
Department of Urology, Med. Hochschule Hannover, Germany
49
Department of Urology, Academic Medical Center, University of Amsterdam, The Netherlands
50
Department of Urology, Hospital 12 Octobre, Madrid, Spain
51
Department of Pathology, Vivantes Krankenhaus Am Urban, Berlin, Germany
52
Department of Oncology, Velindre Hospital, Whitchurch, UK
53
Department of Medical Oncology, Southampton General Hospital, UK
54
Department of Radiooncology, Universita¨t Ko¨ln, Germany
55
Department of Hemato-Oncology, Oregon Health & Science University, USA
56
Department of Urology, Instituto Nazional Tumori, Milano, Italy
57
Department of Oncology, St. Barholomew’s Hospital, London, UK
58
Department of Oncology, St. Elisabeth Cancer Institute, Bratislava, Slovak Republic
59
Department of Urology, Academish Ziekenhuis, Maastricht, The Netherlands
60
Department of Urology, Hospital 12 de Octubre, Madrid, Spain
61
Department of Urology, Instituto Nazionale Tumori, Milan, Italy
62
Department of Oncology, Kaiser-Franz-Josef-Hospital, Vienna, Austria
63
Urologist, Hamburg, Germany
64
Department of Oncology, St. Barholomew’s Hospital. London, UK
65
Department of Hemato-Oncology, REHA-Klinik Reinhardsho¨he, Bad Wildungen, Germany
66
Department of Oncology, Instituto Oncologico Romagnolo, Forli, Italy
67
Department of Urology, Instituto Nazionale Tumori, Milan, Italy
68
Department of Radiooncology, Universita¨t Tu¨bingen, Germany
69
Department of Urology, Krankenhaus Koblenz, Germany
70
Department of Radiooncology, Universita¨t Mainz, Germany
71Department of Hemato-Oncology, Martin-Luther-Universita¨t, Halle, Germany
Department of Oncology-Pathology, Radiumhemmet Karolinska Hospital, Stockholm, Sweden
14
Department of Oncology, CRLC Val d’Aurelle, Montpellier, France
15
Department of Oncology, Rigshospitalet, Finsen Center, Kopenhagen, Denmark
16
Department of Internal Medicine, Oncology, University Hospital Nijmegen, The Netherlands
17
Department of Oncology, Kaiser St. Josef Hospitel, Vienna, Austria
18
Department of Hemato-Oncology, Krankenhaus Neuko¨lln, Berlin, Germany
19
Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands
20
Department of Hemato-Oncology, Sta¨dt. Kliniken, Frankfurt, Germany
21
Department of Urology, Albertinen-Hospital, Hamburg, Germany
22
Department of Hemato-Oncology, Universita¨t Charite´ Mitte, Berlin, Germany
23
Department of Oncology, Medical Centre Leon Berard, Lyon, France
24
Department of Hemato-Oncology, Universita¨t Hannover, Germany
25
Department of Hemato-Oncology, Institute Gestave Roussy, Villejuif, France
26
Department of Medical Oncology, Centre Leon Berard, Lyon, France
27
Department of Radiooncology, The Norwegian Radium Hospital, Oslo, Norway
28
Department of Oncologia Medica, Hospital Furan 1 Reynals, Hospitalet de Llobregat, Spain
29
Department of Oncology, Universita¨t Essen, Germany
30
National Institute of Oncology, Budapest, Hungary
31
Oncologist, Mu¨nchen, Germany
32
Department of Medical Oncology, Institut Catala d’Oncologia, Barcelona, Spain
33
Department of Hemato-Oncology, Hospital, St. Gallen, Switzerland
34
Department of Hemato-Oncology, Universita¨t Tu¨bingen, Germany
35
Urologist, Hamburg, Germany
36
Department of Urology, Universita¨t Ko¨ln, Germany
37
Department of Urology, Kaiser-Franz-Josef Hospital, Vienna, Austria
38
Department of Radiotherapy and Oncology, The Royal Marsden Hospital, Sutton, UK
39
Department of Radiotherapy and Oncology, The Royal Marsden Hospital, Sutton, UK
40
Department of Urology, Princess Margaret Hospital, Toronto, Canada
41
Department of Oncology, Macmillan Consultant in Medecal, Leeds, UK
42
Department of Radiotherapy, Cookridge Hospital, Leeds, UK
43
Department of Urology, Ferenc Jahn South-Pest Teaching Hospital. Budapest, Hungary
44
Department of Oncology, Trondheim University Hospital, Norway
45
Department of Urology, Universita¨t Mu¨nster, Germany
46
Department of Urology, Theresienkrankenhaus, Mannheim, Germany
47
Department of Oncology, British Columbia Cancer Agency, Vancouver, Canada
48
Department of Urology, Med. Hochschule Hannover, Germany
49
Department of Urology, Academic Medical Center, University of Amsterdam, The Netherlands
50
Department of Urology, Hospital 12 Octobre, Madrid, Spain
51
Department of Pathology, Vivantes Krankenhaus Am Urban, Berlin, Germany
52
Department of Oncology, Velindre Hospital, Whitchurch, UK
53
Department of Medical Oncology, Southampton General Hospital, UK
54
Department of Radiooncology, Universita¨t Ko¨ln, Germany
55
Department of Hemato-Oncology, Oregon Health & Science University, USA
56
Department of Urology, Instituto Nazional Tumori, Milano, Italy
57
Department of Oncology, St. Barholomew’s Hospital, London, UK
58
Department of Oncology, St. Elisabeth Cancer Institute, Bratislava, Slovak Republic
59
Department of Urology, Academish Ziekenhuis, Maastricht, The Netherlands
60
Department of Urology, Hospital 12 de Octubre, Madrid, Spain
61
Department of Urology, Instituto Nazionale Tumori, Milan, Italy
62
Department of Oncology, Kaiser-Franz-Josef-Hospital, Vienna, Austria
63
Urologist, Hamburg, Germany
64
Department of Oncology, St. Barholomew’s Hospital. London, UK
65
Department of Hemato-Oncology, REHA-Klinik Reinhardsho¨he, Bad Wildungen, Germany
66
Department of Oncology, Instituto Oncologico Romagnolo, Forli, Italy
67
Department of Urology, Instituto Nazionale Tumori, Milan, Italy
68
Department of Radiooncology, Universita¨t Tu¨bingen, Germany
69
Department of Urology, Krankenhaus Koblenz, Germany
70
Department of Radiooncology, Universita¨t Mainz, Germany
71Department of Hemato-Oncology, Martin-Luther-Universita¨t, Halle, Germany
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