We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.
CITATION STYLE
Sun, J., Zheng, S. L., Wiklund, F., Isaacs, S. D., Purcell, L. D., Gao, Z., … Xu, J. (2008). Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nature Genetics, 40(10), 1153–1155. https://doi.org/10.1038/ng.214
Mendeley helps you to discover research relevant for your work.