A synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring is reported. An expedient synthetic route involving nucleophilic aromatic substitution, and sequential Niementowski and BOP-mediated ring closures afforded a collection of analogues. The scope of the reaction was explored in terms of cyclic and acyclic linkers, ring size and substitution pattern.
CITATION STYLE
Hensbergen, A. W., Mills, V. R., Collins, I., & Jones, A. M. (2015). An expedient synthesis of oxazepino and oxazocino quinazolines. Tetrahedron Letters, 56(46), 6478–6483. https://doi.org/10.1016/j.tetlet.2015.10.008
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