Extensive peritoneal lavage decreases postoperative C-reactive protein concentrations: a RCT

Abstract

Although extensive lavage is useful in peritoneal infections as diverticulitis, the extent of peritoneal lavage that should be used at the end of surgery is unclear. A randomised controlled trial comparing standard lavage with 0.5 litre (L) with extensive 8-L lavage was performed in 20 consecutive patients, following a full thickness resection of the rectum for deep endometriosis. Randomisation was done by the research nurse using sealed envelopes. Endpoints were C-reactive protein (CRP) concentration, white blood cell (WBC) count, temperature and the occurrence of complications. After lavage with 8 L, the CRP concentrations were consistently lower than that after lavage with 0.5 L and this from day 1 to day 7 after surgery (P = 0.01). Rigorous peritoneal lavage seems preferable when a risk of pelvic contamination exists. Clinicaltrials.gov registration: NCT00930696