We compared the allele and genotype frequencies of SCN1A SNP rs3812718 between patients with MTLE-HS of south Indian ancestry with and without febrile seizures (FS) and with ethnically matched controls. While we observed no significant difference in allele and genotype frequencies of rs3812718 between MTLE-HS patients with and without FS, A allele and AA genotype were overrepresented in MTLE-HS patients when compared to controls. We conclude that in the population studied, although rs3812718 polymorphism increases the susceptibility to MTLE-HS, this is not by increasing the susceptibility to FS. © 2012 Elsevier B.V.
CITATION STYLE
Balan, S., Vellichirammal, N. N., Banerjee, M., & Radhakrishnan, K. (2012). Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis. Epilepsy Research, 101(3), 288–292. https://doi.org/10.1016/j.eplepsyres.2012.04.009
Mendeley helps you to discover research relevant for your work.