DNA variation at the FGF20 gene has been associated with Parkinson's disease (PD). In particular, SNP rs12720208 in the 3' untranslated region (3' UTR) was linked to PD-risk through a mechanism that would implicate a differential binding to microRNA-433 (miR-433). The reduction of the affinity of miR-433 to the 3' UTR would result in increased FGF20 expression and upregulation of alpha-synuclein, which could in turn promote dopaminergic neurons degeneration. We genotyped the rs12720208 SNP in a total of 512 PD patients and 258 healthy controls from Spain, and searched for miR-433 variants in the patients. We did not find significant differences in allele and genotype frequencies between patients and controls. None of the patients had miR-433 variants. In conclusion, our work did not confirm the association between rs12720208 and PD, or an effect of miR-433 variants on this disease. © 2010 Elsevier Ireland Ltd.
CITATION STYLE
de Mena, L., Cardo, L. F., Coto, E., Miar, A., Díaz, M., Corao, A. I., … Alvarez, V. (2010). FGF20 rs12720208 SNP and microRNA-433 variation: No association with Parkinson’s disease in Spanish patients. Neuroscience Letters, 479(1), 22–25. https://doi.org/10.1016/j.neulet.2010.05.019
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