A genetic association between the fibroblast growth factor 20 (FGF20) gene and Parkinson's disease has been found by the pedigree disequilibrium test. This association, however, was not replicated by a case-control association study. In order to clarify the association between the FGF20 gene and Parkinson's disease, we attempted to replicate this association by a case-control association study using a large number of Japanese samples (1388 patients and 1891 controls). rs1721100 exhibited a significant difference in allele C versus G (P=0.0089), and in genotype CC+CG versus GG (P=0.0053). Haplotype association analysis showed that haplotype 2 was the protective haplotype for Parkinson's disease (permutation-P=0.0075). These results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population. © 2007 Lippincott Williams & Wilkins, Inc.
CITATION STYLE
Satake, W., Mizuta, I., Suzuki, S., Nakabayashi, Y., Ito, C., Watanabe, M., … Toda, T. (2007). Fibroblast growth factor 20 gene and Parkinson’s disease in the Japanese population. NeuroReport, 18(9), 937–940. https://doi.org/10.1097/WNR.0b013e328133265b
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