Background: Posttransplant cell tracking, via stem cell labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures and functionalities of polysaccharides, proteins, and lipids allow their utilization in nanotechnology systems. Materials and methods: In the present study, we analyzed the potential benefit of curcumin-loaded nanoparticles (NPC) using Vero cells (in vitro) and NPC-labeled adipose-derived mesenchymal stem cells (NPC-ADMSCs) (in vivo) in myocardial infarction and sciatic nerve crush preclinical models. Thereafter, transplantation, histological examination, real time imaging, and assessment of tissue regeneration were done. Results: Transplanted NPC-ADMSCs were clearly identified and revealed potential benefit when used in cell tracking. Conclusion: This approach may have broad applications in modeling labeled transplanted cells and in developing improved stem cell therapeutic strategies.
CITATION STYLE
Mogharbel, B. F., Francisco, J. C., Irioda, A. C., Dziedzic, D. S. M., Ferreira, P. E., de Souza, D., … de Carvalho, K. A. T. (2018). Fluorescence properties of curcumin-loaded nanoparticles for cell tracking. International Journal of Nanomedicine, 13, 5823–5836. https://doi.org/10.2147/IJN.S171099
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