Functional CLOCK gene rs1554483 G/C polymorphism is associated with susceptibility to alzheimer's disease in the chinese population

Abstract

Objective: To examine the association between the circadian locomotor output cycles kaput (CLOCK) gene rs1554483 G/C polymorphism and susceptibility to Alzheimer's disease in Chinese people. Methods: This case-control study determined apolipoprotein E (APOE) and CLOCK rs1554483 G/C genotypes using polymerase chain reaction restriction fragment length polymorphism. Results: Unrelated patients with Alzheimer's disease (n1/4130) and healthy controls (n1/4188) were analysed for an association between the CLOCK gene rs1554483 G/C polymorphism and susceptibility to Alzheimer's disease. In the whole sample and in APOE ε4 isoform noncarriers, the prevalence of CLOCK gene rs1554483 G allele carriers was significantly higher in patients with Alzheimer's disease than in controls. Among APOE ε4 carriers, the prevalence of CLOCK rs1554483 G allele carriers was not significantly different between patients with Alzheimer's disease and controls. Conclusion: Among APOE 4 noncarriers, but not APOE 4 carriers, the CLOCK rs1554483 G allele was associated with increased susceptibility to Alzheimer's disease. © The Author(s) 2013.