The adipose tissue expansion is accompanied by remodeling of extracellular matrix performed by matrix metalloproteinases (MMPs). Higher plasma and tissue MMP-9 levels are found in obese; therefore, we evaluated if the functional C-1562T polymorphism (rs3918242) located in promoter region of the MMP-9 gene is associated with obesity in women. We studied 112 lean and 114 obese women. Plasma MMP-9 and tissue inhibitor of MMP-9 (TIMP)-1 were measured using enzyme-linked immunosorbent assay. We found different genotype frequencies between lean and obese women (p=0.008), prevailing T-allele in obese (2.3-fold). However, although obese women present higher levels of plasma MMP-9, lack of modulation by the polymorphism was found (all p>0.05). Our findings suggest that C-1562T polymorphism may contribute to pathogenetic mechanisms involved in the development of obesity in women. © Copyright 2012, Mary Ann Liebert, Inc.
CITATION STYLE
Andrade, V. L., Fernandes, K. S., Bosco, A. A., Tanus-Santos, J. E., & Sandrim, V. C. (2012). Functional polymorphism located in MMP-9 gene promoter is strongly associated with obesity. DNA and Cell Biology, 31(6), 1054–1057. https://doi.org/10.1089/dna.2011.1526
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