Abstract
Benzo[a]pyrene (BaP) metabolism was studied in pyloric caeca microsomes of the sea star, Asterias rubens. BaP metabolites were identified by HPLC retention and quantified radiometrically. BaP was metabolized into phenols, quinones and dihydrodiols. Monohydroxylated BaP comprised about 40% of the total metabolites produced. Protein adducts of BaP appeared to be formed. Cumene hydroperoxide or NADH also supported BaP metabolism, causing a shift towards dihydrodiol and quinone formation, and at a total rate of metabolism higher than with NADPH. © 1992.
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CITATION STYLE
den Besten, P. J., O’Hara, S. C. M., & Livingstone, D. R. (1992). Further characterization of benzo[a]pyrene metabolism in the sea star, Asterias rubens L. Marine Environmental Research, 34(1–4), 309–313. https://doi.org/10.1016/0141-1136(92)90126-7
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