Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions. © 2011 Elsevier Ltd.
CITATION STYLE
Chiang, H. L., Lee-Chen, G. J., Chen, C. M., Chen, Y. C., Lee, C. M., Liao, M. H., & Wu, Y. R. (2012). Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson’s disease. Parkinsonism and Related Disorders, 18(4), 391–393. https://doi.org/10.1016/j.parkreldis.2011.12.014
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