Genetic association between the IL2RA and mode of onset of type 1 diabetes in the Japanese population

  • Kawasaki E
  • Awata T
  • Ikegami H
  • et al.
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Abstract

Context/Objective: The interleukin-2 receptor alpha (IL2RA), also known as CD25, is expressed on the regulatory T cells which play an important role in the control of immune responses and the maintenance of immune homeostasis. Our objective was to determine whether variants in the IL2RA gene are associated with type 1 diabetes in the Japanese population. Design/Patients: We genotyped the four single-nucleotide polymorphisms (SNPs) (rs706778, rs3118470, ss52580101 and rs11594656) of the IL2RA in 885 patients with type 1 diabetes and 606 control subjects of Japanese origin. The allele and genotype frequencies were examined in the patient groups stratified by their mode of onset in a case-control study. Results: We found evidence of association with acute-onset, but not slow-onset and fulminant, type 1 diabetes for two of the 4 SNPs genotyped (rs706778 and rs3118470). The rs706778 A allele and the rs3118470 G allele were associated with an increased disease risk (Odds ratio [OR] for rs706778 AA genotype 1.54, P = 4.2 x 10(-4) and OR for rs3118470 GG genotype 1.50, P = 0.0019, respectively). Furthermore, the A-G haplotype was associated with increased type 1 diabetes risk in acute-onset form (OR 1.30, P = 0.002). Conclusions: The present data confirmed the type 1 diabetes association with IL2RA and provide evidence that the different contributions of the IL2RA in the susceptibility to acute-onset and other forms of type 1 diabetes in the Japanese population

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Kawasaki, E., Awata, T., Ikegami, H., Kobayashi, T., Maruyama, T., Nakanishi, K., … Eguchi, K. (2008). Genetic association between the IL2RA and mode of onset of type 1 diabetes in the Japanese population. J Clin Endocrinol Metab. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19106270

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