Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants

Abstract

Aims: The aim of this study was to evaluate the combined contribution of 12 genetic variants to the risk of coronary heart disease (CHD). Methods: Through a comprehensive literature search for genetic variants involved in the CHD association study, we harvested a total of 10 genes (12 variants) for the current meta-analyses. These genes consisted of GPX1 (rs1050450), PPARD (rs2016520), ALOX15 (rs34210653), SELPLG (rs2228315), FCGR2A (rs1801274), CCL5 (rs2107538), CYP1A1 (rs4646903), TP53 (rs1042522), CX37 (rs1764391), and PECAM1 (rs668, rs12953, and rs1131012). Results: A total of 45 studies among 23,314 cases and 28,430 controls were retrieved for the meta-analyses of 12 genetic variants. The results showed a significant association between the GPX1 rs1050450 polymorphism and CHD (odd ratio (OR) = 1.61, 95% confidence interval (CI) = 1.25-2.07, P = 0.0002). Other meta-analyses of the rest 11 variants suggested a lack of association with the risk of CHD. Conclusion: Our results confirmed that GPX1 rs1050450 was associated with susceptibility to CHD in Chinese and Indian populations. © 2013 Elsevier B.V.