Objective Results from the published studies on the association of adiponectin gene (ADIPOQ) polymorphisms with blood lipids and blood pressure are conflicting. We investigated the association of three ADIPOQ polymorphisms, +45 T > G (rs2241766), +276 G > T (rs1501299) and-11377 C > G (rs266729), with these traits in this meta-analysis. Research design and methods We included 35 studies in this meta-analysis. Dominant models were used for this meta-analysis. Results We did not detect a significant association of the-11377 C > G polymorphism with blood lipids or blood pressure (P > 0·05). The association of the +45 T > G polymorphism with blood lipids and blood pressure was, similarly, not significant (P > 0·05). The meta-analysis suggested a significant overall association of the +276 G > T polymorphism with lower levels of total cholesterol: weighted mean difference (WMD) =-0·10, 95% confidence interval (CI,-0·17,-0·03), P = 0·005, Pheterogeneity = 0·04. This association was marginally significant in East Asians and East Asians with type 2 diabetes: WMD =-0·10, 95% CI (-0·20, 0·00), P = 0·05, P heterogeneity = 0·002, and WMD =-0·09, 95% CI (-0·18,-0·00), P = 0·05, Pheterogeneity = 0·80, respectively. After exclusion of a study that was the source of heterogeneity, the association was significant in overall populations and marginally significant in East Asians: WMD=-0·06, 95% CI (-0·11,-0·01), P = 0·01, Pheterogeneity = 0·98, and WMD =-0·06, 95% CI (-0·12, 0·00), P = 0·07, Pheterogeneity = 0·83, respectively. However, none of these associations were significant after Bonferroni correction (significant threshold: P < 0·003). Conclusions Our meta-analysis does not suggest any association of the three ADIPOQ polymorphisms with blood lipids and blood pressure. © 2011 Blackwell Publishing Ltd.
CITATION STYLE
Zhao, T., & Zhao, J. (2011). Genetic effects of adiponectin on blood lipids and blood pressure. Clinical Endocrinology, 74(2), 214–222. https://doi.org/10.1111/j.1365-2265.2010.03902.x
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