Background and Purpose-In a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden. Methods-We examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies. Results-No significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13). Conclusions-The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations. © 2010 American Heart Association, Inc.
CITATION STYLE
Olsson, S., Melander, O., Jood, K., Smith, J. G., Lövkvist, H., Sjögren, M., … Jern, C. (2011). Genetic variant on chromosome 12p13 does not show association to ischemic stroke in 3 Swedish case-control studies. Stroke, 42(1), 214–216. https://doi.org/10.1161/STROKEAHA.110.594010
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