Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor, we conducted a genome-wide association study in 757 individuals with Wilms tumor (cases) and 1,879 controls. We evaluated ten SNPs in regions significantly associated at P < 5 × 10 -5 in two independent replication series from the UK (769 cases and 2,814 controls) and the United States (719 cases and 1,037 controls). We identified clear significant associations at 2p24 (rs3755132, P = 1.03 × 10 -14; rs807624, P = 1.32 × 10 -14) and 11q14 (rs790356, P = 4.25 × 10 -15). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate association signals at 5q14, 22q12 and Xp22. © 2012 Nature America, Inc. All rights reserved.
CITATION STYLE
Turnbull, C., Perdeaux, E. R., Pernet, D., Naranjo, A., Renwick, A., Seal, S., … Rahman, N. (2012). A genome-wide association study identifies susceptibility loci for Wilms tumor. Nature Genetics, 44(6), 681–684. https://doi.org/10.1038/ng.2251
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