Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P combined = 2.8 × 10 -40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, P combined = 6.9 × 10 -17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P combined = 7.4 × 10 -11, OR = 1.20) and 6p21.3 (rs3817963, P combined = 2.7 × 10 -10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma. © 2012 Nature America, Inc. All rights reserved.
CITATION STYLE
Shiraishi, K., Kunitoh, H., Daigo, Y., Takahashi, A., Goto, K., Sakamoto, H., … Kohno, T. (2012). A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nature Genetics, 44(8), 900–903. https://doi.org/10.1038/ng.2353
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