Genomics, transcriptomics, and proteomics of the ischemic heart

Abstract

Recurring ischemia and hypertension present the major risk factors for coronary artery disease with its main acute (myocardial infarction) and chronic (chronic heart failure) manifestations. Both pathologies have a strong genetic basis. To unravel the complexity of these conditions, biomedical research is evolving from reductionism focusing on specific candidate genes toward a more integrative view ('systems biology')- Based on newly available high-throughput technologies, evidence is accumulating that genetic variability and altered gene and protein expression contribute significantly to pathophysiologic outcomes. Data from "omics" studies will help to develop novel, more individualized therapeutic approaches in coronary artery disease.