Carbon nanotubes are unique one-dimensional macromolecules with promising application in biology and medicine. Since their toxicity is still under debate, here we describe an investigation of genotoxic properties of purified single-walled carbon nanotubes (SWCNT), multiwall carbon nanotubes (MWCNT), and amide-functionalized purified SWCNT. We used two different cell systems: cultured human lymphocytes where we employed cytokinesis-block micronucleus test and human fibroblasts where we investigate the induction of DNA double-strand breaks (DSBs) employing H2AX phosphorylation assay. © 2013 Springer Science+Business Media New York.
CITATION STYLE
Nešković, O., Joksić, G., Valenta-Šobot, A., Cvetićanin, J., Trpkov, D., Leskovac, A., & Petrović, S. (2013). Genotoxic assessment of carbon nanotubes. Methods in Molecular Biology, 991, 315–323. https://doi.org/10.1007/978-1-62703-336-7_29
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