Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P = 1.91 × 10- 14; OR = 3.94; 95% CI = 2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P = 0.033; OR = 4.21; 95% CI = 1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P = 0.019; OR = 0.41; 95% CI = 0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE. Crown Copyright © 2008.
CITATION STYLE
Lin, Y. J., Wan, L., Sheu, J. J. C., Huang, C. M., Lin, C. W., Lan, Y. C., … Tsai, F. J. (2008). G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan. Clinical Immunology, 129(1), 36–39. https://doi.org/10.1016/j.clim.2008.05.011
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