Headspace gas chromatography with capillary column for urine alcohol determination

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Abstract

A headspace gas chromatographic method using a fused-silica capillary column Poraplot Q has been developed and validated for the detection and quantification of ethanol in urine. Under optimized conditions, ethanol was properly separated from acetaldehyde, acetone, isopropanol, methanol and n-propanol. Limits of detection (LODs) and quantification (LOQs) were 0.008 and 0.010 g/l, respectively. The precision studies within-run and between-run, using spiked urine samples (0.08, 0.8 and 2.0 g/l) showed maximum coefficients of variation 5.9 and 6.5%, respectively. Results of ethanol recovery varied from 91.6 ± 0.8 to 103.3 ± 1.8% over the concentration range from 0.01 to 3.20 g/l. The method was appropriate for the detection of ethanol in urine samples. This matrix can be used for monitoring alcohol abuse in the workplace and used in alcohol rehabilitation programs.

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Corrêa, C. L., & Pedroso, R. C. (1997). Headspace gas chromatography with capillary column for urine alcohol determination. Journal of Chromatography B: Biomedical Applications, 704(1–2), 365–368. https://doi.org/10.1016/S0378-4347(97)00445-3

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