OBJECTIVE: To examine in overweight humans the short-term safety and efficacy for weight loss of an herbal supplement containing Ma Huang, Guarana and other ingredients. DESIGN: An 8 week randomized, double-blind placebo controlled study of a herbal dietary supplement (72 mg/day ephedrine alkaloids and 240 mg/day caffeine). SUBJECTS: Overweight men and women (body mass index, >= 29 and < 0.006) greater loss of weight (X+/-s.d., -4.0+/-3.4kg) and fat (-2.1+/-3.0% fat) over the 8-week treatment period than did placebo (- 0.8+/-2.4kg and 0.2+/-2.3% fat). Active treatment also produced greater reductions in hip circumference and serum triglyceride levels. Eight of the 35 actively treated subjects (23%) and none of the 32 placebo-treated control subjects withdrew from the protocol because of potential treatment-related effects. Dry mouth, insomnia and headache were the adverse symptoms reported most frequently by the herbal vs placebo group at the final evaluation visit. CONCLUSIONS: This herbal mixture of Ma Huang and Guarana effectively promoted short-term weight and fat loss. Safety with long-term use requires further investigation.
CITATION STYLE
C.N., B., J.A., N., S.B., H., V., W., G., C., & J.L., S. (2001). An herbal supplement containing Ma Huang-Guarana for weight loss: A randomized, double-blind trial. International Journal of Obesity. C.N. Boozer, New York Obesity Research Center, St. Luke’s-Roosevelt Hosp. Center, 1111 Amsterdam Avenue, New York, NY 1002S, United States. E-mail: cnb7@columbia.edu. Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed5&NEWS=N&AN=2001100176
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