Recently, the rs3129882 variant in intron 1 of HLA-DRA was found to be associated with late-onset sporadic Parkinson disease (PD) in Americans of European ancestry. To evaluate whether the same variant is related to PD in Chinese population, we investigated late-onset sporadic PD patients of Chinese Han ethanicity in Mainland China. We found significant difference in genotypic and allele distribution between patients and control subjects (χ 2=6.446, p=0.040 for genotypic distribution; χ 2=5.762, p=0.016 for allele distribution), suggesting this variant is associated with late-onset sporadic PD in Chinese Han population. © 2011 Elsevier Ireland Ltd.
CITATION STYLE
Guo, Y., Deng, X., Zheng, W., Xu, H., Song, Z., Liang, H., … Deng, H. (2011). HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease. Neuroscience Letters, 501(3), 185–187. https://doi.org/10.1016/j.neulet.2011.05.245
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