Human formyl peptide receptor 1 C32T SNP interacts with age and is associated with blood pressure levels

Abstract

Background: Human formyl peptide receptor 1 (FPR1) mediates inflammatory responses, recognized as important participants in the physiopathology of hypertension. Similarly, FPR1 C32T SNP is associated with inflammation and BP related pathways. Therefore, the relationship between FPR1 C32T SNP, BP and hypertension needs to be investigated. Method: 1012 French middle-aged adults including 491 healthy individuals (5years follow-up, T +0 and T +5) and 521 hypertensive individuals were PCR-RFLP genotyped for FPR1 C32T SNP (rs5030878). Results: At entrance, there was no significant association between FPR1 C32T SNP and blood pressure (BP) in healthy individuals. However, 5years later , significant associations were found for DBP, SBP (p<0.001 and p=0.009 respectively) and for their 5years changes (δ) (p=0.025 and p=0.027 for DBP and SBP respectively). Significant interactions between FPR1 C32T SNP and age on DBP, SBP, δDBP and δSBP were found (p=0.014, 0.008, 0.015 and 0.015 respectively). Consequently, stronger increase in BP was reported among healthy individuals aged less than 45years. When normotensive individuals were compared to hypertensives ones, similar FPR1 C32T genotypes and allele frequency distributions were found. Conclusion: FPR1 C32T SNP interacts with age, is associated with higher and a 5 years increase of BP levels in healthy individuals aged less than 45 years. © 2010 Elsevier B.V.