Sign up & Download
Sign in

The human Mi-2/NuRD complex and gene regulation.

by S A Denslow, P A Wade
Oncogene ()

Abstract

The Mi-2/nucleosome remodeling and deacetylase (NuRD) complex is an abundant deacetylase complex with a broad cellular and tissue distribution. It is unique in that it couples histone deacetylation and chromatin remodeling ATPase activities in the same complex. A decade of research has uncovered a number of interesting connections between Mi-2/NuRD and gene regulation. The subunit composition of the enzyme appears to vary with cell type and in response to physiologic signals within a tissue. Here, we review the known subunits of the complex, their connections to signaling networks, and their association with cancer. In addition, we propose a working model that integrates the known biochemical properties of the enzyme with emerging models on how chromatin structure and modification relate to gene activity.

Cite this document (BETA)

Readership Statistics

116 Readers on Mendeley
by Discipline
 
 
 
by Academic Status
 
34% Ph.D. Student
 
16% Post Doc
 
10% Student (Bachelor)
by Country
 
4% United States
 
2% Canada
 
1% Switzerland

Sign up today - FREE

Mendeley saves you time finding and organizing research. Learn more

  • All your research in one place
  • Add and import papers easily
  • Access it anywhere, anytime

Start using Mendeley in seconds!

Already have an account? Sign in