A recent study used a network modeling strategy to generate a set of genes linked by potential functional associations. The hyaluronan-mediated motility receptor (HMMR) gene was identified as being as functionally associated with BRCA1 and thus a candidate breast cancer gene. SNPs rs10515860, rs299290, and rs7712023 were reported to be significantly associated with breast cancer in a joint analysis of two small case-control studies. We have examined the association of these single nucleotide polymorphisms, together with others tagging the HMMR gene, in a larger, European case-control study and find no association of any of them with risk of breast cancer: rs10515860 [odds ratio (OR; AA/ GG), 0.85; 95% confidence interval (CI), 0.65-1.12; Ptrend = 0.9], rs299290 [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; Ptrend = 0.7], rs3756648 (rs7712023) [OR(TT/CC), 0.93; 95% CI, 0.84-1.02; Ptrend = 0.1], rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; Ptrend = 0.5], and rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; Ptrend = 0.6]. Copyright © 2008 American Association for Cancer Research.
CITATION STYLE
Kalmyrzaev, B., Pharoah, P. D. P., Easton, D. F., Ponder, B. A. J., & Dunning, A. M. (2008). Hyaluronan-mediated motility receptor gene single nucleotide polymorphisms and risk of breast cancer. Cancer Epidemiology Biomarkers and Prevention, 17(12), 3618–3620. https://doi.org/10.1158/1055-9965.EPI-08-0216
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