Hybrid approaches combine computational modeling techniques with low-resolution structural data. Such approaches have proven to be powerful tools to obtain new 3D structural and dynamical information on biological systems. Currently, major applications focus on cryo-EM data. Methods and some applications to construct atomic structural models of new functional states will be reviewed. In addi- tion, possible extension to data from X-ray free electron laser, which currently provides low-resolution data, will be discussed.
CITATION STYLE
MIYASHITA, O., & TAMA, F. (2017). Hybrid Approach for Biological Structure Modeling: Cryo-electron Microscopy and X-ray Free Electron Laser Data. Seibutsu Butsuri, 57(2), 090–094. https://doi.org/10.2142/biophys.57.090
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