Patient genetic make-up may contribute to a higher risk for acute rejection episodes (AREs). Because interleukin-2 (IL2) and IL2 receptor β (IL2RB) play key roles in immune modulation, we investigated the effect of single-nucleotide polymorphisms (SNPs) in the IL2 gene (rs2069762; T>G, promoter; and rs2069763; G>T, exon 1, Leu38Leu) and IL2RB gene (rs228942: C>A, exon 1, Asp391Glu; and rs228953: C>T, exon 8, Gly250Gly) on renal ARE risk in 61 ARE patients and 276 control renal allograft recipients in Korea. The genotype frequencies of the IL2 and IL2RB SNPs showed Hardy-Weinberg equilibrium in both ARE and control groups. No significant difference in the genotype frequencies of the 2 IL2 SNPs was detected between non-ARE and ARE subjects (P >.05). The occurrence of AREs was significantly associated with genetic variants of the IL2RB gene (rs228942: odds ratio [OR] 2.11, 95% confidence interval [CI] 1.193.74; P =.0096, dominant model; rs228953: OR 1.58, 95% CI 1.042.38; P =.029, codominant model). In the haplotype-based analysis, the AC haplotype of IL2RB (χ 2 = 4.738; P =.0295) showed associations with ARE. Our results demonstrate that genetic variants of IL2RB may be associated with the development of AREs and may help predict ARE risk in kidney transplantation patients. © 2011 by Elsevier Inc. All rights reserved.
CITATION STYLE
Park, S. J., Yoon, Y. C., Kang, S. W., Kim, T. H., Kim, Y. W., Joo, H., … Kim, Y. H. (2011). Impact of IL2 and IL2RB genetic polymorphisms in kidney transplantation. Transplantation Proceedings, 43(6), 2383–2387. https://doi.org/10.1016/j.transproceed.2011.06.014
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