Inactivity and muscle: Effect of resistance training during bed rest on muscle size in the lower limb

Abstract

The present study aimed to investigate the effect of dynamic leg press training on the physiological cross-sectional areas (PCSAs) of human lower limb muscles during 20 days of 6° head-down tilt bed rest. Five healthy men comprised the resistance training group (BR-Tr) and data from two previous studies were used to derive a 10-man control group (BR-Cont). The BR-Tr performed two sessions (morning and afternoon session) of dynamic leg press action including knee extension and plantar flexion daily for the bed rest period: (1) three sets of 10 repetitions at 90% of maximum load and (2) 40% of maximum load to exhaustion. The PCSAs of the knee extensor (KE), knee flexor (KF), plantar flexor (PF), and dorsiflexor muscle groups were estimated using serial axial magnetic resonance (MR) images of the right-thigh and leg. After the bed rest period, the BR-Tr showed a significant increase in the PCSA of the KE. Although PCSA of the KF in two groups significantly decreased after bed rest, percentage of change in PCSA of the biceps femoris (long head) and semitendinosus muscles in the BR-Tr, which occupied approximately 70% of the KF, was significantly higher than those in the BR-Cont. Both the BR-Tr and BR-Cont groups showed significant decreases in the PCSA of PF with similar magnitude of 11.6% (P < 0.001) and 11.9% (P < 0.001), respectively. These results suggest that dynamic leg press training during bed rest can prevent deteriorating of the KE and a part of KF, but not the calf muscles.