Induced Correlation In FMRI Magnitude Data From k-Space Preprocessing

Abstract

Correlations between image-space voxels over time have been used to identify functionally connected regions of the cortex of subjects in the “resting state.” The common pre-processing techniques that are applied to fMRI k-space data before image reconstruction and before magnitude image formation can induce image-space voxel correlations. Since connectivity inferences are based upon image-space correlations, one must quantify and account for such pre-processing induced correlations. This framework allows the quantification and removal of these induced correlations. This will enhance and refine all future fMRI connectivity studies.