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Inferring gene regression networks with model trees.

by Isabel A Nepomuceno-Chamorro, Jesus S Aguilar-Ruiz, Jose C Riquelme
BMC bioinformatics ()

Abstract

Novel strategies are required in order to handle the huge amount of data produced by microarray technologies. To infer gene regulatory networks, the first step is to find direct regulatory relationships between genes building the so-called gene co-expression networks. They are typically generated using correlation statistics as pairwise similarity measures. Correlation-based methods are very useful in order to determine whether two genes have a strong global similarity but do not detect local similarities.

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