Investigation of Anthramycin Analogs Induced Cell Death in MCF-7 Breast Cancer Cells

Abstract

1,5-Benzodiazepines were synthesized using chalcone & o-phenylene diamine. Their structures were characterized using physical & spectral data. These molecules are analogous to anthracin, henceforth evaluated for their anti-breast cancer activity, using in vitro model MTT assay against MCF-7 cell line. Results revealed that these molecules are having potential growth inhibitory effect on the MCF-7 cell line, and certainly better than that of standard cisplatin. Docking studies revealed that these 1,5- benzodiazepine molecules may be working by inhibiting tyrosine kinase receptor, ErbB4 of human breast adenocarcinoma cell line(MCF-7/Michigan Cancer Foundation-7). © 2011 IGJPS. All rights reserved.