Isobaric and hyperbaric bupivacaine 0.5% solution for spinal anesthesia

Abstract

The effects of spinal anesthesia with 0.5% isobaric and hyperbaric (8% glucose) bupivacaine were investigated in 45 patients who had lower limb or lower abdominal surgery. The patients were divided into 3 groups. Group 1 patients received 3 ml of 0.5% isobaric bupivacaine. The patients in group 2 and 3 received 3 or 2 ml of 0.5% hyperbaric bupivacaine (8% glucose). Blood pressure dropped in all groups. The decrease in blood pressure was so severe in group 2 that vasopressors were required in 70% of cases. The average segmental level of analgesia was T9 in group 1, C8 in group 2 and T4 in group 3. Complete motor blockade was obtained in all the patients. Time to complete motor blockade of the lower limbs was 12.6 min in group 1, 5.5 min in group 2 and 8.4 min in group 3. Duration of analgesia and motor blockade were 387.4 min and 303.7 min in group 1, 373.5 min and 300.0 min in group 2 and 318.9 min and 228.9 min in group 3. These results suggest that adequate surgical anaesthesia could be obtained with 3 ml of 0.5% isobaric bupivacaine and 2 ml of 0.5% hyperbaric bupivacaine.

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