c-Jun NH2-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family. Like other MAPKs, JNKs are conserved throughout eukaryotic evolution, activated via three-tiered phosphorylation cascades, and involved in a wide range of cellular responses to stress. JNKs have been shown to play important roles in proliferation, cell death, inflammation and cell metabolism. These seemingly unrelated responses are part of an overall stress response program that ensures proper repair of cells sustaining minor damage, elimination of cells sustaining irreversible structural or genetic damage, as well as their proper replacement. © 2010 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Schwabe, R. (2010). JNKs in liver diseases. In Signaling Pathways in Liver Diseases (pp. 215–227). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-00150-5_14
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