A DNA variant, rs734232, altering a RUNX1 binding site was recently reported as susceptibility allele at PSORS2 (17q25) in cohorts of psoriasis patients from the US. A testing of this variant in psoriasis patients from Germany did not confirm this association in 300 trios nor in two case-control studies with 281 patients with psoriasis vulgaris and 375 patients with psoriatic arthritis, respectively. These results fail to support rs734232 as a psoriasis susceptibility factor in German psoriasis patients.
CITATION STYLE
Hüffmeier, U., Traupe, H., Burkhardt, H., Schürmeier-Horst, F., Lascorz, J., Böhm, B., … Reis, A. (2005). Lack of evidence for genetic association to RUNX1 binding site at PSORS2 in different German psoriasis cohorts. Journal of Investigative Dermatology, 124(1), 107–110. https://doi.org/10.1111/j.0022-202X.2004.23571.x
Mendeley helps you to discover research relevant for your work.