Large-scale population study of human cell lines indicates that dosage compensation is virtually complete

115Citations
Citations of this article
110Readers
Mendeley users who have this article in their library.

Abstract

X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivation disrupts dosage compensation. We conclude that dosage compensation is virtually complete. Overall expression from the X chromosome is only slightly higher in females and can largely be accounted for by elevated female expression of approximately 5% of X-linked genes. We suggest that the potential contribution of escape from X chromosome inactivation to phenotypic differences between the sexes is more limited than previously believed. © 2008 Johnston et al.

Cite

CITATION STYLE

APA

Johnston, C. M., Lovell, F. L., Leongamornlert, D. A., Stranger, B. E., Dermitzakis, E. T., & Ross, M. T. (2008). Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. PLoS Genetics, 4(1), 0088–0098. https://doi.org/10.1371/journal.pgen.0040009

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free