Efficient cellular delivery, including plasma membrane permeability and intracellular metabolic stability, is a crucial factor determining the success of therapeutic agents. Cell-penetrating peptides (CPPs) have been widely used for the intracellular delivery of various bioactive molecules into cells to modify cellular functions. We have developed an improved CPP-based cellular delivery vector, named lipo-oligoarginine peptide (LOAP), by conjugating an oligoarginine peptide with a fatty acid moiety. The prepared LOAPs were further stabilized by introducing different combinations of d-Arg residues into the peptide backbone and were systematically evaluated for their membrane-penetrating properties and metabolic stabilities in cells. © 2013 Springer Science+Business Media New York.
CITATION STYLE
Lee, J. S., & Tung, C. H. (2013). Lipo-oligoarginine-based intracellular delivery. Methods in Molecular Biology, 991, 281–292. https://doi.org/10.1007/978-1-62703-336-7_26
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