List of drugs in development for neurodegenerative diseases. Update June 2004.

List of drugs in development for neurodegenerative diseases. Update June 2004.

by Myoung-Ok Kwon, Frauke Fischer, Mark Matthisson, Paul Herrling

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Neurodegenerative Diseases (2004)

Volume: 1, Issue: 2-3, Pages: 37-86

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004509 (1 10 10 bis(2 fluoro 4 pyridinylmethyl) 9(10h) anthr [1 [(1 formyl 2 phenylethyl)carbamoyl] 2 methylpro 1 (4 aminophenyl) 4 methyl 7 1792 17alpha estradiol 1 (benzo[b]thien 5 yl) 2 (2 diethylaminoethoxy)eth 1 bis(3 fluorophenyl)butane 2 21 [4 [5 2 (2 2 (3 pyridinyl)quinuclidine 2 [[4 [2 2 [4 (2 2 [4 methoxy 3 (2 phenylethoxy)phenyl] n 2 [5 (4 dimethylsulfamoylphenyl) 6 2 bis(2 aminophenyl) ether n 2 chloro n [alpha (2 piperidinyl)benzyl] 3 trifluo 2 dipropylamino 5 2 dipropylamino 5 methoxy 1 methyltetralin 2 thiazolidine]3 3 (2 carboxy 2 phenylethenyl) 4 3 (2 carboxy 4 3a 3 allyl 6 chloro 2 3 amino 1 3 amino 1 hydroxy 4 methyl 2 pyrrolidinone 3 aminopropyl(diethoxymethyl)phosphinic acid 3 b 3 benzoselenazine 3 benzothiazol 2 yl)[2 [2 (3 pyridinyl)ethylami 3 d 3 dicarboxycyclopropyl)glycine 3 dihydro 3 3 dihydro 3 isopropyl 2 oxo 1 benzimidazolecarbo 3 dimethylisoquinoline 2 oxide 3 dione 3 ethynyl 5 (1 methyl 2 pyrrolidinyl)pyridine fuma 3 quinoxalinedione 4 4 [[2 (1 methyl 2 pyrrolidinyl)ethyl]thio]phenol 4 (2 fluorophenyl) 6 methyl 2 (1 piperazinyl)thien 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 4 benzothiadiazin 4 bis(1 4 carboxymethylamino 5 4 cyclopentano 1 4 dihydro 2 methyl 3h 4 dihydro 3 4 dihydro 4 4 dimethyl 1 4 tetrahydro 2 isoquinoliny 4 tetrahydro 4 (3 phenylureido)4 tetrahydro 6 5 5 (2 chloro 1 hydroxyethyl) 4 methylthiazole 5 (3 5 [3 [4 (4 fluorophenyl) 1 piperazinyl]propyl] 1 5 (4 chlorophenyl) 4 ethyl 2 5 amino 2 (2 furyl) 7 (2 phenylethyl)pyrazolo[4 5 aminovalerylsubstance p [7 11][9 proline 10 (n m 5 chloro n [4 methoxy 3 (1 piperazinyl)phenyl] 3 m 5 difluorobenzyloxy)phenoxy] 5 ethoxyanili 5 dihydro 5 oxo 4 isoxazolepropionic 5 di tert butyl 4 hydroxybenzylidene) 4 thiaz 5 tetrahydro 7 6 600292 601245 6 (1 imidazolyl) 7 nitro 2 657 6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 pi 6 bis(diethylamino) 2 pyridyl] 1 piperazi 6 dichloro 1h indo 6 dichloro 3 indolyl)propionic acid 6 dimethoxyindan 6 nitro 7 sulfamoylbenzo[f]quinoxaline 2 6 quinoxalinecarboxylic acid piperidide 6 tetramethyl 1 indanyl) 4 (3 m 7 7b12 7 dichloro 1 7 dichloro 2 quinolinecarbo 7 dichloro 5 nitro 2 7 dipropylamino 2 8 8 [4 [3 (5 fluoro 1h indol 3 yl)propyl] 1 piperazi 8 dihydroxy 8 dihydroxy 1 phenyl 1h 3 ben 8 hexahydronaphtho[2 8 methylenedioxy 5h 2 8 tetramethoxy 3 9b tetrahydro 1 benzopyran 9 tetrahydr 9 tetrahydro 9 (2 morpholinoethyl) 2 a 134974 a 35380 a 366833 a 72055 abs 205 abs 301 abs 302 abs 304 abt 089 ac 184897 ac 90222 acea 1021 acp 103 acpc adenosine kinase inhibitor ad gl0002 aeg 3482 aeol 10150 agy 110 agy 207 ak 275 alaptid ale 0540 aloxistatin acid alpha (4 fluorophenyl) 4 (5 fluoro 2 pyrimidinyl)alpha amino 2 altropane alzheimer disease alzheimer disease vaccine am 36 ampakines ampa receptor antagonist analgesic agent anapsos anatibant antiarrhythmic agent anticonvulsive agent antidepressant agent antihypertensive agent antiinflammatory agent antineoplastic agent antioxidant antiparkinson agent antitussive agent anxiety disorder anxiolytic agent apbpi 124 aptiganel ar 139525 ar 15896 ar a 008055 aricept ar r 17779 ar r 18565 arry 142886 arundic acid arx 2000 arx 2001 arx 2002 ascomycin asenapine asthma attention deficit disorder autoimmune disease av 201 avp 923 axokine az 36041 azd 0328 ba 1016 bay 38 7271 bay x 9227 bd 1054 besonprodil bgc 20 1178 bia 3 202 bifeprunox biii 890 cl bimu 8 blonanserin bls 602 bls 605 bms 181100 brain disease brain ischemia brasofensine breflate bts 72664 bvt 2989 bxt 51072 calpastatin cdd 0304 cee 03 310 cee 03 320 central nervous system disease cep 1347 cep 3122 cep 4186 cep 751 cere 120 cere 130 cere 20 cgp 35348 chf 2060 chf 3381 chronic obstructive lung disease ckd 705 clk 1 clomethiazole cnic 568 cns 2103 cns 5065 cognitive defect coleneuramide colostrinin coluracetam coughing cp 132484 cp 283097 cp 465022 cpc 304 cx 516 cyclooxygenase 2 inhibitor dabelotine dar 201 dcg iv dd 20207 decahydro 6 (2h tetrazol 5 ylmethyl) 3 isoquinolin decahydro 6 phosphonomethyl 3 isoquinolinecarboxyl degenerative disease delucemine dementia disufenton sodium dmp 543 donepezil dopamine 2 receptor blocking agent dopamine 3 receptor blocking agent dp 103 dp 109 dp b99 dpp 225 dr 2313 drug effect drug indication drug induced disease drug mechanism dy 9760c e 2007 e 2051 e 2101 eaa 494 eab 318 ect ad ect pd edaravone ef 7412 egis 7444 eglumetad eht 201 eht 202 eliprodil emricasan enteritis ep 475 epilepsy eqa 00 ersofermin es 242 1 ethyleneglycol 1 f 10981 f 2 ccg i farampator fce 29484a fce 29642a fk 506 fk 520 fk 960 flindokalner fluoratec formobactin fpl 16283 fr 210575 galdansetron ganstigmine geomatrix gke 841 glaucoma glialines glycine receptor antagonist gmc 1111 gp 14683 gpi 1485 gr 1485 gr 73632 gt 2342 gt 715 gv 2400 gyki 52466 head injury heart infarction hf 0220 homotaurine hp 184 human huntington chorea hypophysis adenylate cyclase activating polypeptid ibipinabant ica 69673 icosapentaenoic acid ethyl ester idn 6556 ifenprodil igt 440103 immune deficiency immunomodulating agent incontinence indantadol inflammation ino 1001 ipenoxazone isp 1 ispronicline istradefylline kf 17329 kp 102 krp 199 krx 411 kw 6002 l 687306 l 687414 l 689560 l 701252 lactacystin beta lactone ladostigil lamictal lamotrigine lanicemine lau 0501 lau 8080 lax 101 lecozotan lentivector leteprinim liatermine liga 20 liver cirrhosis liver disease lurasidone ly 178002 ly 233536 ly 274614 ly 293558 ly 302427 ly 354006 ly 354740 ly 451395 ly 483518 m 40401 major depression mcc 257 mci 225 mdl 100748 mdl 101002 mdl 102288 mdl 105519 mdl 27266 mdl 28170 mdl 29951 mecasermin mem 1003 mental disease mibampator midafotel migraine mirapex mito 4509 mito 4565 mkc 231 mln 519 mnd 21 monoamine oxidase b inhibitor mood disorder motor neuron disease ms 153 mt 5 multiple sclerosis muscarinic m1 receptor agonist muscle relaxant agent n n (2 hydroxyethylamino) 3 nitronaphthalimide n 3393 n [4 [2 (6 cyano 1 n [4 [2 (8 cyano 1 n (4 acetyl 1 piperazinyl) 4 fluorobenzamide n (7 hydroxy 2 nbi 30702 nc 531 n dipropy ne 100 nebicapone neoplasm neotrofin neramexane nerispirdine nervous system injury neublastin neurocale neuroleptic agent neuropathy neuroprotective agent neurostrol neurotoxicity neurovex nicotinamide adenine dinucleotide adenosine diphos nla 715 n methyl dextro aspartic acid receptor blocking ag nnc 07 0775 nnc 07 9202 noggin nootropic agent norleu norphenazone novasite nox 700 nps 1407 nps 1506 nps 846 nrt 115 ns 1209 ns 1608 ns 2330 ns 257 ns 377 ns 638 ns 649 nt 4 nt 5 nw 1048 nxd 5150 nxd 9062 nxy 059 olanzapine omega conotoxin mviia omigapil ono 2506 opc 14117 org 24448 p 58 p 9939 pacap pain paliroden pan 811 pardoprunox parkinson disease pbt 1 pd 132026 pd 148903 pd 150606 pd 159265 pd 90780 pdc 008 004 pe21 pentoxifylline pentoxyfyllin perampanel perzinfotel pimavanserin pn 277 pn 401 pnu 101033e pnu 157678 pnu 170413 pnu 177864 pnu 87663 pnu 99194a pol 255 polypodium leucotomos extract pozanicline ppi 368 pralmorelin pramipexole pre 103 priority journal prostate tumor prs 211220 psychosis pti 777 pym 50018 pym 50028 qg 2283 qr 333 r 1485 r 1577 recombinant ciliary neurotrophic factor recombinant somatomedin c remacemide ren 1654 ren 1820 respiratory distress syndrome restenosis retigabine review rg 1068 rheumatoid arthritis ri 820 rjr 1401 rjr 2429 ro 09 2210 rocepafant rpr 104632 rs 100642 s 14297 s 14820 s 1746 s 176251 s 18986 s 312 d s 33113 1 s 33138 s 34730 s 34730 1 sarizotan sb 203580 sb 271046 sb 277011 sca 136 sch 58261 schizoaffective psychosis schizophrenia sea 0400 selegiline selumetinib semax senile arch serotonin 2a antagonist sgs 518 sib 1553a sib 1765f siclofen sirenade sja 6017 skf 38393 skf 74652 skf 82958 sl 340026 sl 65 0155 sleep disorder slv 308 slv 314 slv 319 sm 13496 snx 482 spasmolytic agent spc 9766 sph 1371 spinal cord injury spiro[1 azabicyclo[2.2.2]octane 3 spm 914 spm 935 sp (v5.2)c sr 57667 sra 333 ssr 125047 ssr 146977 ssr 180575 ssr 181507 ssr 482073 ssr 504734 sumanirole sun c5174 sun n8075 survivins sym 2207 systemic lupus erythematosus t 588 tacrolimus talampanel talnetant taltirelin tan 950 a tc 1734 tc 2559 tch 346 terestigmine tesofensine tezampanel tgp 580 throphix thurinex tk 14 tp 20 traxoprodil ts 011 u 74500a u 78517f ucm 3100 uh 232 uk 351666 uk 356297 uk 356464 ulcerative colitis unclassified drug unindexed drug v 2006 vabicaserin vasolex vipadenant vp 025 vx 799 way 855 wib 63480 2 win 68100 win 69211 xaliproden xaliprodene y 931 ykp 1358 ym 90k zendra ziconotide zonampanel zt 1 zydis

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List of drugs in development for neurodegenerative diseases. Update June 2004.

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