Looking ahead

Abstract

Therapeutic and research applications of octreotide have escalated in the past 2 years. Its use can be considered almost routine in conditions such as acromegaly and gastroenteropancreatic endocrine tumors. Potential application for acute variceal bleeding, diabetes mellitus, polycystic ovarian syndrome, and acquired immunodeficiency syndrome (AIDS)-related diarrhea seem promising, but require further evaluation in controlled trials. The most exciting recent development-demonstration of somatostatin receptors in a variety of human tumors-opens up therapeutic possibilities for treating carcinoma, including the "targeting" of tumor cells. However, the limiting factor for therapy is the current necessity for repeated daily injections. The availability of an intranasal or long-acting injectable preparation would improve acceptability and compliance. © 1992.