Mammalian sperm nuclear organization: Resiliencies and vulnerabilities

47Citations
Citations of this article
102Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Sperm cells are remarkably complex and highly specialized compared to somatic cells. Their function is to deliver to the oocyte the paternal genomic blueprint along with a pool of proteins and RNAs so a new generation can begin. Reproductive success, including optimal embryonic development and healthy offspring, greatly depends on the integrity of the sperm chromatin structure. It is now well documented that DNA damage in sperm is linked to reproductive failures both in natural and assisted conception (Assisted Reproductive Technologies [ART]). This manuscript reviews recent important findings concerning - the unusual organization of mammalian sperm chromatin and its impact on reproductive success when modified. This review is focused on sperm chromatin damage and their impact on embryonic development and transgenerational inheritance.

Cite

CITATION STYLE

APA

Champroux, A., Torres-Carreira, J., Gharagozloo, P., Drevet, J. R., & Kocer, A. (2016, December 21). Mammalian sperm nuclear organization: Resiliencies and vulnerabilities. Basic and Clinical Andrology. BioMed Central Ltd. https://doi.org/10.1186/s12610-016-0044-5

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free