OBJECTIVE: We sought to determine whether maternal genetic variants associated with glucose homeostasis in genome-wide association studies are associated with infant birth weight. STUDY DESIGN: We genotyped 866 self-identified Caucasian women and 397 self-identified African-American women in the Pregnancy, Infection and Nutrition (PIN) Studies cohorts for 37 ancestry-informative markers and for 20 single-nucleotide polymorphisms (SNPs) associated with glucose homeostasis in European populations. We used linear regression to model the effect of genotype on birth weight z-score, adjusting for pregravid BMI, maternal age and probability of Yoruban ancestry. P values of<0.05 were considered statistically significant. RESULTS: The mean birth weight among study participants was 3278g (SD 650, mean sex-adjusted z-score 0.00) for Caucasian and 2956g (SD 728, mean sex-adjusted z-score-0.46) for African-American infants. Among Caucasian participants, we found an inverse association between carriage of the rs11605924 risk allele and birth weight (perallele change -0.10, 95% CI -0.20 to -0.01, p=0.03). This SNP is located in the intron region of CRY2, a gene implicated in circadian rhythm regulation. We found a direct association between rs2237892 risk allele carriage and birth weight z-score (per-allele change 0.31, 95% CI 0.09 to 0.53, p=0.01). This SNP is located in the intron region of KCNQ1, a gene on chromosome 11 that is abnormally imprinted in Beckwith-Wiedemann syndrome. We further found a direct association between rs4607517 and z-score (per allele change 0.29, 95% CI 0.06 to 0.52, p=0.01). This SNP is located in an intergenic region adjacent to GCK. Mutations in GCK are associated with non-insulin dependent diabetes mellitus and hyperinsulinemic hyperglycemia of infancy. We found no associations between genotyped SNPs and zscores among African-American participants in our cohort. CONCLUSION: We found that three SNPs associated with glucose homeostasis are also associated with birth weight z-scores. These loci may play a role in associations between maternal hyperglycemia and birth weight..
CITATION STYLE
A., S., A., H., A., W., & A.M., S.-R. (2012). Maternal genotype and infant birth weight z-score. American Journal of Obstetrics and Gynecology, 206(1), S118. Retrieved from http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L70632992;
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