Objective: MicroRNA plays a vital role in gene expression, and microRNA dysregulation is involved in carcinogenesis. The miR- 196a-2 polymorphism rs11614913 is reportedly associated with cancer susceptibility. This meta-analysis was performed to assess the overall association of miR-196a-2 with cancer risk. Methods: A total of 27 independent case-control studies involving 10, 435 cases and 12, 075 controls were analyzed for the rs11614913 polymorphism. Results: A significant association was found between rs11614913 polymorphism and cancer risk in four genetic models (CT vs. TT, OR=1.15, 95%CI=1.05-1.27; CC vs. TT, OR=1.23, 95%CI=1.08-1.39; Dominant model, OR=1.17, 95%CI=1.06-1.30; Additive model, OR=1.08, 95%CI=1.01-1.14). In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectal cancer, but not with liver, gastric, or esophageal cancer. In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup. Conclusions: The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations. © 2012 by Cancer Biology & Medicine.
CITATION STYLE
Zhang, H., Su, Y. L., Yu, H., & Qian, B. Y. (2012). Meta-analysis of the association between miR-196a-2 polymorphism and cancer susceptibility. Cancer Biology and Medicine, 9(1), 63–72. https://doi.org/10.3969/j.issn.2095-3941.2012.01.012
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